Virus detection and its association with symptoms during influenza-like illness in a sample of healthy adults enrolled in a randomised controlled vaccine trial

PF Howard; JM Mccaw; PC Richmond; M Nissen; T Sloots; SB Lambert; M Lai; M Greenberg; T Nolan; J Mcvernon

Journal article

Virus detection and its association with symptoms during influenza-like illness in a sample of healthy adults enrolled in a randomised controlled vaccine trial

PF Howard, JM Mccaw, PC Richmond, M Nissen, T Sloots, SB Lambert, M Lai, M Greenberg, T Nolan, J Mcvernon

Influenza and Other Respiratory Viruses | WILEY | Published : 2013

DOI: 10.1111/j.1750-2659.2012.00395.x

Abstract

Background Viral respiratory infections are associated with significant morbidity and mortality. Many new aetiological agents have been described recently. Objectives We looked for respiratory viruses in a population-based sample of healthy adults with influenza-like illness (ILI). We investigated host and spatio-temporal associations with virus isolation and host, spatio-temporal and virus associations with self-reported symptoms. Patients/Methods We recruited 586 participants experiencing 651 illness episodes from a population of healthy adults enrolled in an influenza vaccine effectiveness trial. At ILI assessment visits, a respiratory swab was collected and tested for viruses using a com..

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University of Melbourne Researchers

James McCaw Author

Terry Nolan Author

Jodie McVernon Author

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Grants

Awarded by Australian Research Council

Funding Acknowledgements

MN has received travel grants from Wyeth Australia to present independent research at international meetings, and currently and previously has been the principal investigator for clinical trials sponsored by Abbott, Baxter, CSL, GSK, MedImmune, Merck, Novartis, Sanofi-Pasteur, Wyeth, and Pfizer.We thank study staff at the 12 sites for the recruitment of participants and collection of and processing of samples for this substudy. We thank Dale Cooper (CSL Limited) for facilitating study conduct including provision of study data collected by CSL as part of the main vaccine study. Terry Nolan (Vaccination and Immunisation Research Group, Melbourne, Victoria), Peter Richmond (Telethon Institute for Child Health Research, Perth, Western Australia), Jeff Karrasch (Australian Clinical Research Organisation, four sites across Queensland NSW), Helen Marshall (Adelaide Women's and Children's Hospital, Adelaide, South Australia), Sepehr Shakib (CMAX, Adelaide, South Australia), Fred de Looze (Queensland Trialworks, Queensland), John McBride (James Cook University, Cairns, Queensland), Maree O'Sullivan (Hobart Sexual Health Service, Hobart, Tasmania) and Walter Abhayaratna (Australian National University, Canberra, Australian Capital Territory) led the investigation at participating sites. We thank Dr Julie Simpson for statistical advice. This research was supported by an Australian Research Council Linkage Project (LP0989464) with support from CSL Limited, Victoria, Australia. Jodie McVernon is supported by a National Health and Medical Research Council (Australia) Career Development Award (566635).